The mediastinum is the most common extragonadal location. In adults, approximately % of mediastinal tumors are germ cell tumors;. 20% of mediastinal tumors and cysts; Typically divided into seminomas versus nonseminomatous germ cell tumors (teratomas [mature or. Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. They most commonly occur in the gonad but occasionally.

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Gestational trophoblastic disease Hydatidiform mole Choriocarcinoma Placental site trophoblastic tumor Polyembryoma Gonadoblastoma.

Mediastinal germ cell tumor

The nonteratomatous germinal neoplasms have the same morphologic features, approximate distribution, and prognosis as the gonadal counterparts. The diagnosis of a mediastinal germ cell tumor should be considered meddiastinum all young males with a mediastinal mass. This page was last edited on 2 Augustat Germ cell tumors[TI] mediastinum.

Rare cases of adult onset acute megakaryoblastic leukemia are associated with malignant mediastinal germ cell tumor. Accessed December 31st, Germ cell tumor – mixed.

Germ cell tumors of the mediastinum.

By using this site, you agree to mediatinum Terms of Use and Privacy Policy. The intense staining pattern of OCT4 and the high sensitivity of FISH make them superior to mediastinun auxiliary diagnostic utilities for detecting seminoma.

Pancoast tumor Solitary pulmonary nodule Central lung Peripheral lung Bronchial leiomyoma. Non-small-cell lung carcinoma Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.


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Germinoma with yolk sac component. Excised tumor with rib. Germinoma-seminoma is the most frequent nonteratomatous malignant germ cell tumor.

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Most mediastinal malignant tumors are large and cause symptoms by compressing or invading adjacent structures, including the lungs, pleura, pericardium, and chest wall.

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Metastatic germ cell tumor: Page views in to date: These results and those of other analyses suggest that the two malignancies derive from a common founding clone of cells i.

Pathology by systems F.

Epidemiology Usually males Gross description Invasive, highly necrotic Microscopic histologic description Poorly differentiated, pleomorphic cells with prominent mwdiastinum, often with eosinophilic intracellular globules or primitive lumina; variable geographic necrosis No nuclear blebs Microscopic histologic images Images hosted on other servers: These tumors are highly sensitive to radiation therapy and to combination chemotherapy.

The anterior mediastinum is the most common primary extragonadal site for germinal neoplasms in adults mediaastinum is second to the sacrococcygeal region for pathologially comparable tumors in children.

mediastinal germinoma – – Human pathology

Retrieved from ” https: Click here for information on linking to our website or using our content or images. Initial treatment with four courses of bleomycin, etoposide, and cisplatin, followed by surgical resection of any residual disease, germinomx considered standard therapy.


Germinoma with multilocular thymic cyst. Fine needle aspiration biopsy can establish diagnosis with high degree of accuracy Am J Clin Pathol ; May have aggressive behavior if not limited to mediastinum at diagnosis Cancer ; Among the malignant germ cell tumors, males are affected far more commonly than females, but the male to female ratio is approximately equal among mature cystic teratomas.

Immunohistochemical staining for OCT4 has recently been validated as a powerful tool for detecting gonadal seminoma. Epidemiology Usually men in 20s with elevated hCG and gynecomastia, impotence Prognostic factors Poor prognosis Case reports 13 year old boy with shortness of breath, chest pain, fever, irritable cough and weight loss Zhongguo Dang Dai Er Ke Germinpma Zhi ; Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum.

In these cases, the mediastinal germ cell tumor develops before or concomitantly with but not after acute megakaryoblastic leukemia. Views Read Edit View history. Patients with small tumors usually asymptomatic that appear resectable usually undergo thoracotomy and attempted complete resection followed by chemotherapy.