Histoid leprosy is a skin condition, a rare form of multibacillary leprosy See also[edit]. Leprosy · Skin lesion. References[edit]. ^ James, William D.; Berger. Histoid leprosy, an uncommon variant of lepromatous leprosy, develops usually as relapse in lepromatous patients who are on dapsone. Summary Histoid leprosy is a rare multibacillary form that presents with disseminated papule-nodular cutaneous lesions. To study the inflammatory infiltrate.

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Uday Khopkar for histopathological report and granting permission for publication. Histopathology of the lower back nodule showed atrophic epidermis with a subepidermal grenz zone.

Facies with relics of LL such as infiltration, loss of eyebrows, and depressed nose may be present or absent [ 1 ]. The spindled histiocytes resemble fibroblasts and it hiatoid suggested that these fibroblast-like macrophages may have arisen from tissue histiocytes rather than from blood monocytes [ 9 ].

In addition to lepromatous histoidd LLit may occasionally be seen in unstable borderlineand indeterminate leprosygroups. Multiple grouped shiny nodules over bony prominences. The histoid leproma can occur during the early stages of LL or borderline LL.

Histoid leprosy

Received Oct 20; Accepted Dec Dermatol Online J ; It is essential to continue the surveillance for new case, rather than to wait for voluntary reporting since early diagnosis and complete treatment are important to achieve our goal of elimination of leprosy. Int J Dermatol ; In this phase of the National Program of Leprosy Eradication, a high index of suspicion is essential to continue the surveillance for new and relapse cases, rather than to wait for voluntary reporting.


J Hitsoid Dev Ctries. Abstract Histoid leprosy, an uncommon variant of lepromatous leprosy, develops usually as relapse in lepromatous patients who are on dapsone monotherapy, but uncommonly arises de novo. Responsible factors may include: Abstract Histoid leprosy is an uncommon entity with specific clinical, histopathological and bacteriological features. The enormous bacillary population in histoid lesions is suggested to be due to focal loss of immunity [ 4 ].

Hiwtoid of Clinical and Diagnostic Research.

De Novo Histoid Leprosy

Classical histopathological findings include epidermal atrophy as a result of dermal expansion of the underlying leproma and a grenz zone located immediately below the epidermis. Histoid leprosy as reservoir of the disease; a challenge to leprosy elimination.

The third pattern is most commonly observed [ 8 lepros. It is so-called because the microscopic appearance of the nodule shows spindle-shaped cells resembling those in a dermatofibroma. The patient is responding to the treatment, with no ENL till month followup.

Histoid Leprosy

This article has been cited by 1 Curcumin could prevent methemoglobinemia induced by dapsone in rats Mateus M. The impact of the entity on the postglobal leprosy elimination era.


Br J Dermatol ; Actinomycetaceae Actinomyces israelii Actinomycosis Cutaneous actinomycosis Tropheryma whipplei Whipple’s disease Arcanobacterium haemolyticum Arcanobacterium haemolyticum infection Actinomyces gerencseriae. Histoid leprosy as reservoir of the disease; a challenge to leprosy elimination.

The patient responded well to the treatment. Introduction Histoid leprosy is a well-recognized entity.

In India, its incidence among leprosy patients has been estimated to be between 2. Author information Article notes Copyright and License information Disclaimer. Lepra histoire de Wade. A year-old young male, an agricultural laborer, complained of multiple asymptomatic shiny nodules all over the body.

Histoid leprosy is a distinct and rare variant of lepromatous leprosy, and it was described by Wade 1 in Histopathological findings are unique. Each of them can be differentiated from the histoid leprosy on the basis of its characteristic histopathology, the absence of lepra bacilli on slit skin smear and nerve thickening.

Within the mass of spindle-shaped histiocytes, rounded-polygonal plump histiocytic cells with vacuolated cytoplasm along with occasional giant cells were noticed Figures 2 a — 2 c.